Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 2

Year

2020 1

2008 1

Keywords

CGRP excretion 1

calcitonin gene-related 1

cerebrum 1

computer 1

diabetic kidney disease 1

miR-154-5p 1

subsequent ischemia/reperfusion 1

type 2 diabetes mellitus 1

urinary albumin to creatinine ratio 1

open ︾

Search scope:

排序： Display mode:

The early signal substances induced by heat stress in brains of mice

WANG Chunxu, WANG Hanxing

Frontiers of Medicine 2008, Volume 2, Issue 4, Pages 391-395 doi: 10.1007/s11684-008-0075-1

Abstract: the expression of cAMP response element binding protein (CREB) and calcitonin gene-related peptide (CGRPCompared to the normal group, heat stress could result in CGRP excretion and redistribution in the cerebrumFollowing heat stress, CGRP immunoreactivity was observed in varicose fibers and neuronal perikarya withinThe results indicate that heat stress can induce CREB expression, which in turn stimulates CGRP secretion

Keywords： calcitonin gene-related subsequent ischemia/reperfusion computer cerebrum CGRP excretion

HTML PDF Collect

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Frontiers of Medicine 2020, Volume 14, Issue 5, Pages 642-650 doi: 10.1007/s11684-019-0719-3

Abstract: This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinine ratio (UACR) in patients with type 2 diabetes mellitus (T2DM) and the association with biomarkers of inflammation and fibrosis in diabetic kidney disease (DKD). A total of 390 patients with T2DM were divided into three groups: normal albuminuria (UACR<30 mg/g, =136, NA), microalbuminuria (UACR at 30–300 mg/g, =132, MA), and clinical albuminuria (UACR>300 mg/g, =122, CA). Circulating miR-154-5p, inflammatory (C-reactive protein (CRP); erythrocyte sedimentation rate (ESR); and tumor necrosis factor-α (TNF-α) and fibrotic markers (vascular endothelial growth factor (VEGF); transforming growth factor-β1 (TGF-β1); and fibronectin (FN)), and other biochemical indicators were assessed via real-time PCR, enzyme-linked immunosorbent assay, and chemiluminescence assay in patients with T2DM and 138 control subjects (NC). UACR, miR-154-5p, glycated hemoglobin (HbA1c), serum creatinine (sCr), blood urea nitrogen (BUN), ESR, CRP, VEGF, TNF-α, TGF-β1, and FN were significantly higher and the estimated glomerular filtration rate (eGFR) was significantly lower in NA, MA, and CA groups than in NC subjects ( <0.05). Elevated levels of UACR and miR-154-5p were directly correlated with HbA1c, sCr, BUN, ESR, CRP, VEGF, TNF-α, TGF-β1, and FN and negatively correlated with eGFR ( <0.05). miR-154-5p, HbA1c, sCr, BUN, eGFR, ESR, CRP, VEGF, TNF-α, TGF-β1, and FN were important factors affecting UACR. These findings indicated that elevated serum miR-154-5p is significantly correlated with high UACR in patients with T2DM and may offer a novel reference for the early diagnosis of DKD.

Keywords： type 2 diabetes mellitus diabetic kidney disease miR-154-5p urinary albumin to creatinine ratio